Living soft tissues appear to promote the development and maintenance of apreferred mechanical state within a defined tolerance around a so-called set-point . This phenomenon is often referred to as mechanical homeostasis . We present a novel finiteelement based computational framework that is constructed bottom up . It models key mechanobiological mechanisms such as actin cytoskeletoncontraction and molecular clutch behavior of individual cells interacting with a reconstructed three-dimensional extracellular fiber matrix . This model can serve as asystematic tool for future in silico studies of the origin of the numerous still unexplained experimental observations about mechanical homestasis . The frameworkreproduces many experimental observations on short time scales (hours), in which the deposition and degradation of extracecular matrix can largely be neglected .

Author(s) : Jonas F. Eichinger, Maximilian J. Grill, Iman Davoodi Kermani, Roland C. Aydin, Wolfgang A. Wall, Jay D. Humphrey, Christian J. Cyron

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Keywords : mechanical - matrix - observations - soft - tissues -

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